Enclomiphene Citrate For Ovulation Induction

Clomiphene citrate clomiphene is the most commonly used drug for ovulation induction since it is inexpensive highly effective and user friendly. Clomiphene citrate for ovulation induction. 18 although the dose required to achieve ovulation correlates with body weight there is no reliable way to predict accurately what dose will be required in an individual woman.

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In anovulatory women ovulation rates conception rates and pregnancy outcome are similar regardless whether treatment begins on cycle day 2 3 4 or 5.

Enclomiphene citrate for ovulation induction. Clomiphene citrate has been the most widely used treatment for fertility enhancement for the past 40 years. That is the first line method of ovulation induction in women with anovulatory infertility. Clomiphene was a revolutionary advance in reproductive medicine and quickly became popular for induction of ovulation because of its ease of administration and minimal side effects. Clomiphene used in conjunction with a medication called provera may be effective in initiating menstruation and ovulation in women who have no menstrual cycle.

It constitutes the treatment of choice in hyperandrogenic chronic anovulation. 19 consequently cc induction of ovulation amounts to an. Since 1962 it has been the drug of choice for oral ovulation induction over the last 50 years 3 5. According to american society for reproductive medicine european society of human reproduction and embryology clomiphene citrate cc is the recommended first line treatment for polycystic ovary syndrome pcos because it is readily available cheap well tolerated with a good safety and efficacy profile 1 2 3 a commonly used cc protocol for ovulation induction involves a starting dose of.

Treatment begins with a 5 7 day course of provera taken orally. Clomiphene can induce ovulation in 80 of anovulatory women but only 40 of women became pregnant. It was first synthesized in 1956 and has been commercially available since 1961. Since cis clomiphene citrate cc used for ovulation induction may affect embryo implantation during in vitro fertilization direct effects of the drug on human endometrium were tested.