Letrozole Protocol For Ovulation Induction

Letrozole is more effective than clomiphene for ovulation induction in women with pcos and bmi 30 3 kg m 2 legro and colleagues 1 randomly assigned 750 women with anovulatory infertility and pcos to receive ovulation induction with either clomiphene or letrozole.

Letrozole protocol for ovulation induction. J obstet gynaecol can 2007. The medications were prescribed using an escalating dose if ovulation did not occur. Forman r gill s moretti m et al. How do aromatase inhibitors work.

The traditional protocol using letrozole for ovulation induction is identical to the protocol used with cc. It is estimated that polycystic ovary syndrome pcos affects 1 in 10 women of childbearing age and it is the most common cause of ovulatory infertility. This replaces the practice bulletin number 108 published october 2009 which recommends letrozole as first line therapy for ovulation induction only in women with pcos and a bmi greater than 30. Comparison of the pregnancy outcomes and the incidence of fetal congenital abnormalities in infertile women treated with letrozole and clomiphene citrate.

Typical treatment begins with the lowest dose of the medication for 5 days starting on cycle day 3 5 after a spontaneous menses or after a progestin induced withdrawal bleed. Akbari sene a ghorbani s ashrafi m. Listing a study does not mean it has been evaluated by the u s. Fetal safety of letrozole and clomiphene citrate for ovulation induction.

Letrozole step up protocol for ovulation induction in infertile women with pcos the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Letrozole is a medication that has been widely used in women with breast cancer it is sold under the trade name femara.